We have previously identified and characterized three subpopulations of CSCs within liver metastasis from colon adenocarcinoma (LMCA): a SOX2+/NANOG+/KLF4+/c-Myc+/OCT4+ subpopulation and a SOX2+/NANOG+/KLF4+/c-Myc+/OCT4− subpopulation confined to the peritumoral stroma (PTS), and a SOX2+/NANOG+/KLF4+/c-Myc+/OCT4− subpopulation within the tumor nests (TNs) (12). This evidence concerns the gene SOX2 and colon adenocarcinoma.