Indeed, in endometriosis, a gynecological disease with dysregulated proliferation of endometrial stromal cells closely resembling that of the dysregulated proliferation of fibroblasts in SSc, wild-type mice bearing endometrial implants from nrf2-KO-horn display an aggravated phenotype, with elevated volume of the implants and higher amounts of collagen and inflammatory markers compared to those with implants from wild-type animals (37). Here, NFE2L2 is linked to female reproductive system disorder.