IL-6 was also involved in the induction of BNIP3 through the activation of Jak/Stat3 signaling (113, 114), and the suppression of IL-6/Jaks/Stat3 signaling might contribute to the inhibition of Bnip3-mediated apoptosis and autophagy in ConA-induced hepatitis (29). This evidence concerns the gene STAT3 and Hepatitis.