The previous study of luciferase activity test showed that ARC could inhibit the IFN-γ/Stat1 and IL-6/Stat3 signaling (122), while present study demonstrated the inhibitions of both IFN-γ/IL-6/Stat1 signaling and IL6/Bnip3 signaling contributed to the protective effects of ARC against ConA-induced hepatitis. Here, STAT3 is linked to Hepatitis.