PROM1 and central nervous system cancer: PROM1 has been identified in colorectal, hepatocellular, and pancreatic cancer43, as one of the most important markers of tumor-initiating cells and an adverse prognostic factor in colon cancer, gliomas, and medulloblastoma43,44, and is associated with decreased survival in a variety of human tumors, including brain, colorectum, endometrium, gliomas, liver, medulloblastoma, NSCLC, ovary, and stomach45,46.