For this purpose, we tested the effects of the Aurora-A inhibitor alisertib in mouse mammary tumor cell lines derived from Tp53–/–;Brca2wt/wt or Tp53–/–;Brca2F11/F11 mice (denoted as Brca2wt/wt, Brca2F11/F11). The gene discussed is TP53; the disease is breast cancer.