As demonstrated in Fig. 6e, f), ICG-001 effectively suppressed EGF- or high SHCBP1-induced tumorigenesis in vivo, further supporting that the CBP/β-catenin interaction is important for EGF/SHCBP1-induced stem cell-like properties in NSCLC. Here, SHCBP1 is linked to non-small cell lung carcinoma.