Moreover, we also found that SHCBP1 is generally up-regulated in multiple cancer types in addition to NSCLC, including glioma, HCC, and breast cancer, suggesting that upregulation of SHCBP is not an NSCLC-specific event but instead might be attributed to genetic or epigenetic mechanisms commonly active in various types of cancer. Here, SHCBP1 is linked to hepatocellular carcinoma.