Of note, we also observed such an EGF-induced SHCBP1 dissociation from SHC1 and nuclear translocation without change of SHCBP1 expression in the A549 NSCLC cell lines as well (Fig. 2a, c–e), and no correlation between EGFR mutation and SHCBP1 expression could be found in The Cancer Genome Atlas (TCGA) dataset (http://cancergenome.nih.gov/) (Fig. 2f). Here, SHC1 is linked to non-small cell lung carcinoma.