Our results demonstrated that the ICG-001 compound effectively suppressed EGF-induced formation of tumor cell spheres, expression of stemness markers as well as Survivin, drug resistance against Cisplatin (Fig. 4g, h, Supplementary Figs. 4d, e and Supplementary Table S2), suggesting that the CBP/β-catenin interaction is important for EGF induced stem cell-like phenotype in NSCLC. The gene discussed is BIRC5; the disease is non-small cell lung carcinoma.