In addition to NSCLC, SHCBP1 was also widely up-regulated in breast cancer, glioma and hepatocellular carcinoma (HCC), as shown by our analyses of the GEO datasets (GSE4290, GSE45114, and GSE29174) (Supplementary Fig. 7a), suggesting that aberrant expression of SHCBP1 might be a common event in human cancers. Here, SHCBP1 is linked to central nervous system cancer.