As shown in Fig. 5c–e, Supplementary Figs. 5a, b, and Supplementary Table S3, stable NSCLC cell lines expressing ectopic SHCBP1 displayed increased stem cell characteristics as evidenced by forming more and larger cellular spheres in suspension culture, elevated Survivin expression, and increased resistance to cisplatin. Here, BIRC5 is linked to non-small cell lung carcinoma.