Notably, in two NSCLC cell lines carrying activating mutation of EGFR, HCC827, and HCC4006, we also found that the EGF-induced nuclear translocation of SHCBP1 could be blocked by pre-incubation with the EGFR TKI gefitinib (Fig. 2j), indicating that the above described events occurred in an EGFR tyrosine kinase-dependent manner. This evidence concerns the gene EGF and non-small cell lung carcinoma.