By contrast, at least 5 × 104 vector-control A549 cells were needed to form a tumor (Fig. 6c, d, and Supplementary Table S6), altogether indicating that high-level SHCBP1 is able to promote NSCLC cell stemness and tumorigenesis (Supplementary Fig. 6). This evidence concerns the gene SHCBP1 and non-small cell lung carcinoma.