By performing IHC assay and chi-square test in 50 NSCLC specimens, we found that tumors with higher nuclear SHCBP1 expression usually display higher level of β-catenin signaling downstream genes Axin2, Ccnd1, and Survivin as shown in Fig. 8c, suggesting that nuclear SHCBP1 played an important role in β-catenin activation in NSCLC. Here, SHCBP1 is linked to non-small cell lung carcinoma.