MYC and adenoma: As observed in adenomas, c-Myc and E2F target genes were significantly enriched among the downregulated RNAs in AP4-deficient organoids (Fig. 8a, Supplementary Fig. 8c, Supplementary Data 2) albeit with rather modest fold changes in expression that were considerably less pronounced compared with those of ISC signature and Notch target genes (Supplementary Fig. 8f, Supplementary Data 2).