When we analyzed ChIP-Seq data, which we had previously obtained after ectopic AP4 expression in the CRC cell line DLD-17, we detected AP4 occupancy at the ASCL2, DLL1, DLL4, EPHB3, HES1, JAG1, JAG2, NOTCH1, SOX4 and TCF7 promoters in human DLD-1 CRC cells (Supplementary Fig. 9g). This evidence concerns the gene HES1 and colorectal carcinoma.