ZEB1 and gastric cancer: To address the molecular mechanisms by which Brg1 contributes to gastric cancer cell migration and tumor metastasis, we examined a series of well-characterized EMT regulators such as Snail, ZEB-1, Twist-1 and β-catenin in AGS in a doxycycline (DOX)-based Brg1 inducible system (Fig. 5a).