FBXW7 and gastric cancer: Moreover, in keeping with a pivotal role for CK1δ in governing Fbw7-mediated ubiquitination of Brg1, depletion of endogenous CK1δ in gastric cancer cells MKN45 and AGS, resulted in a marked increase in protein abundance of endogenous Brg1 (Fig. 2e and Supplementary Figure 3d).