FBXW7 and gastric cancer: In addition, IHC analyses revealed that the protein level of Brg1 was inversely correlated with FBW7 expression in gastric cancer specimens (Fig. 3g, h), indicating that Brg1, as an ubiquitin substrate of FBW7, was upregulated in gastric cancer in part due to decreased FBW7 expression that subsequently resulted in compromised enzymatic activity of the SCFFBW7 E3 ligase complex.