Aside from the biallelic inactivation of VHL, according to recent studies, common genetic alterations that are most recurrently found in ccRCC patients often target genes controlling the expression of epigenetic regulator proteins involved in modulating chromatin conformation and accessibility to transcription, such as PBRM1, SETD2, BAP1, ARID1A, KDM5C, and KDM6A [41]. This evidence concerns the gene PBRM1 and nonpapillary renal cell carcinoma.