The following terms were used and adapted for the searches in each database: (polypoidal choroidal vasculopathy or PCV) and (vascular endothelial growth factors or anti-VEGF or angiogenesis inhibitors or ranibizumab or lucentis or bevacizumab or avastin or aflibercept) and (photodynamic therapy or PDT). The gene discussed is VEGFA; the disease is Polypoidal choroidal vasculopathy.