CXCR3 and breast carcinoma: In MDA-MB-435 and MCF-7 breast cancer cells, CXCR3 and CXCL10 are upregulated via the Ras signaling pathway, which contributes to breast cancer development [20], suggesting that CXCL10-CXCR3 autocrine function may play an essential role in breast cancer motility and metastasis.