CXCR3 and breast cancer: A. canaliculatum ethanolic extract (ACE) inhibits TNFα-induced migration of MDA-MB-231 metastatic breast cancer cells and prevents TNFα-induced CXCR3 and CXCL10 expression through inhibition of the IκB kinase (IKK)-mediated NF-κB pathway(Figure 9B).