Prx II regulates stemness-associated characteristics of cancers via several pathways, mainly including VEGF/VEGFR/STAT3, Ras/FoxM1, JNK, Wnt/β-Catenin, Hedgehog and androgen (AR)/androgen receptor signaling [19,20,21,22,43,91]. The gene discussed is MAPK8; the disease is cancer.