In conscious rats, chronic inhibition of NO by l-NAME resulted in sustained hypertension while blockade of AT1 receptor produced little effect on blood pressure (BP), blockade of α adrenergic receptors resulted in moderate fall in BP while combined blockade of AT1, and α adrenergic receptors produced profound drop in pressure indicate that chronic inhibition of NO, hypertension is due to combined stimulation of AT1 and α adrenergic receptors [108]. Here, AGTR1 is linked to hypertensive disorder.