The transient increase in the respiratory rate in WT MEFs 24 h following rapamycin addition in our study was somewhat surprising given that other groups studying myotubes (Cunningham et al., 2007; Ye et al., 2012), leukemic Jurkat T cells (Ramanathan and Schreiber, 2009; Schieke et al., 2006) or T-cell lymphoma (Kittipongdaja et al., 2015) did not find mTOR inhibition to stimulate the respiratory rate and in most cases found a decreased rate of respiration. This evidence concerns the gene MTOR and T-cell non-Hodgkin lymphoma.