Emerging evidence suggests that the interaction of IgA1 with various receptors on mesangial cells results in SYK activation, although the potential of signaling via other receptors (including FcRγ, integrins, or C-type lectin receptors on resident on infiltrating cells) has yet to be explored specifically in IgA nephropathy. Here, FCER1G is linked to IgA glomerulonephritis.