NEDD4 and brain neoplasm: Whereas simultaneous overexpression of Nedd4 and Ndfip barely exhibited any effect on brain tumor phenotype caused by vps35 mutation (Figure 6—figure supplement 1A–C), coexpression of Su(dx) and Ndfip indeed led to a complete rescue of the supernumerary neuroblast phenotype in vps35 mutants (Figure 6A,B).