Nevertheless, poorly differentiated cell lines mimicked upregulated expression of genes (in tumours) such as CAV1, COL4A1, and novel candidates such as TSPAN5, TENM2, C15orf48, PLAU, AHNAK2, FAM129A, PLAU and platelet-specific phosphofructokinase (PFKP) (Fig. 1c). The gene discussed is TENM2; the disease is neoplasm.