HK2 and breast cancer: Subsequently, BCAR4 activates Hedgehog effector GLI2 and forms a BCAR4/GLI2/p300 complex, which directly activates the transcription of downstream target glycolysis-related genes HK2 and PFKFB3 (6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3) through acetylation of H3K27ac histones, and ultimately promotes the glycolysis of breast cancer cells [38].