WWTR1 and neoplasm: The Hippo signaling pathway is a highly conserved tumor suppressor pathway, which mainly comprises mammalian Ste20-like kinases 1/2 (MST1/2) and large tumor suppressor 1/2 (LATS1/2), yes association protein (YAP) and/or its paralog TAZ (also known as WW domain containing transcription regulator 1 (WWTR1).