Instead, other signaling pathways also induce YAP/TAZ activation and nuclear localization at transcriptional and post-translational levels, such as Wnt/β-catenin signaling pathway [22, 23], JNK signaling pathway [24] and Rho-GTPs signaling pathways [25], even in tumor cell energy metabolism [26, 27]. The gene discussed is WWTR1; the disease is neoplasm.