AFP and hepatocellular carcinoma: Various efforts have been made to improve survival rates through early screening methods based on serum alpha-fetoprotein (AFP) and liver ultrasound, which are the most widely used methods for HCC screening; however, with a sensitivity of 25% to 65% for AFP and 60% for ultrasound, the detection of a disease with such a high impact through these methods is remains suboptimal [7].