RBM38 and cancer: RBPs are involved in the expression of various genes responsible for biological processes and cellular functions [22, 24, 25] via deregulation of splicing factors, which might lead to alternative splicing of transcripts and mRNA translation of tumor-suppressor genes or oncogenes in cancer cells [23, 26].The RNA binding motif protein 38 (RBM38) belongs to the RRM family of RBPs, whose gene is located on chromosome 20q13 and expressed in various tissues.