RBPs are involved in the expression of various genes responsible for biological processes and cellular functions [22, 24, 25] via deregulation of splicing factors, which might lead to alternative splicing of transcripts and mRNA translation of tumor-suppressor genes or oncogenes in cancer cells [23, 26].The RNA binding motif protein 38 (RBM38) belongs to the RRM family of RBPs, whose gene is located on chromosome 20q13 and expressed in various tissues. Here, RBM38 is linked to neoplasm.