TIAM1 and lung carcinoma: In accordance with the role of Tiam1 in maintaining the cell junction structure, Vaughan et al. have shown that in response to HGF, Tiam1 can be ubiquitinated at Lys-595 by HUWE1, resulting in Tiam1 degradation and disassembly of cell junctions, increasing cell migration and invasion in lung carcinoma cells [126].