HUWE1 and hepatocellular carcinoma: During obesity-associated hepatocellular carcinoma (HCC) development, expression of interleukin-6 (IL-6), which results from a chronic low-grade proinflammatory state in white adipose tissue and liver [101], helps to stabilize Mcl-1 via promotion of GSK3β inactivation and suppression of HUWE1 [102].