Excessive amount of Skp2 results in a loss of p27 and this oncogenic role of Skp2, corresponding to up-regulation of Skp2 in tumor tissues, has been observed in a wide range of human cancers, including lung, breast, colorectal, head and neck squamous cell carcinoma (HNSCC) [12–14]. The gene discussed is SKP2; the disease is head and neck squamous cell carcinoma.