HUWE1 and medulloblastoma: HUWE1 plays a significant role in Group 2 sonic hedgehog (SHH)-type of medulloblastoma by regulating the turnover of the basic helix-loop-helix (bHLH) transcription factor, Atoh1, which prevents differentiation of cerebellar granule neuron progenitors (GNPs) and enhances medulloblastoma (MB) formation [66, 70].