Interestingly, in sarcoid samples we have also observed the presence of numerous small vessels, immunostained with vWF, which appeared often irregular in shape These findings were in agreement with other studies, which reported that tumor vasculature, formed under the influence of VEGF, is often structurally and functionally abnormal [42], probably as the results of the insufficient production or activation of other angiogenic factors, necessary for the formation of mature and functioning new vessels [25, 26]. This evidence concerns the gene VWF and neoplasm.