VEGF is a potent angiogenic factor, produced by a variety of cell types, including keratinocytes, endothelial cells, macrophages, mast cells, fibroblasts [29, 34, 35] and is involved in several types of tumors [23–27], where it has been shown to influence both tumor neovascularization and dissemination [36, 37]. Here, VEGFA is linked to neoplasm.