The MVDs were immunohistochemically assessed by means of two endothelial markers: von Willebrand factor (vWF or FVIII related antigen), a pan-endothelial marker [22], which illustrates the metabolic demand of the tumor [23]; and endoglin (CD105), a marker of proliferating endothelial cells [24], which reflects the degree of angiogenesis [23]. The gene discussed is VWF; the disease is neoplasm.