Upregulation of Tenascin C has also been linked to growth factors and cytokines such as TGFβ1, interleukin 1 and TNFα (Rettig et al., 1994), which have been associated with retinal degenerative disorders (Eastlake et al., 2016), suggesting that Tenascin C may contribute to gliosis. This evidence concerns the gene TGFB1 and Gliosis.