BRCA1 and breast carcinoma: There are close to 2,000 known BRCA1 germline pathogenic variants, many of which are loss‐of‐function frameshift pathogenic variants.34 Nine of 28 (32%) unique BRCA1 and 6 of 33 (18%) unique BRCA2 pathogenic variants were found to be recurrent in Swedish breast cancer patients (i.e., pathogenic variants that were found to occur in at least two unrelated individuals).