Although no dose-related or cumulative toxicity was apparent in the phase I, open-label study of Siltuximab, an anti-IL-6 monoclonal antibody, in patients of B-cell Non-Hodgkin’s Lymphoma or multiple myeloma (NCT00412321), no responses were seen in patients with relapsed or refractory multiple myeloma treated with single-agent Siltuximab (Table 1). This evidence concerns the gene IL6 and plasma cell myeloma.