IL6 and non-small cell lung carcinoma: In addition, no objective responses were seen in the phase 1/2, multiple-dose, dose-escalation study of siltuximab, suggesting that IL-6 inhibition alone is insufficient in treating advanced or refractory solid tumors including ovarian, pancreatic, colorectal, head & neck cancer and non-small-cell lung carcinoma (NSCLC) (Table 1).