MMP13 and non-small cell lung carcinoma: However, in non-small-cell lung carcinoma, MMP13 has been shown to be consistently and ubiquitously expressed.37 Ultimately the LoD will need to be evaluated in formal prospective diagnostic studies, however excitingly, with more sensitive detectors that are capable of measurements independent of fluorescent intensity that are now emerging,38 we expect this to be ample for detection.