Pharmacologically inhibiting the HIF hydroxylases promotes HIF-1α accumulation and improves cardiac function following ischemia-reperfusion in diabetic rats.PerspectivesCOMPETENCY IN MEDICAL KNOWLEDGE: Cardiovascular disease is the leading cause of death in patients with type 2 diabetes, with increased mortality and accelerated progression into heart failure following myocardial infarction. The gene discussed is HIF1A; the disease is heart failure.