HIF-1α plays a vital role in the survival of cardiomyocytes following ischemia (2), and decreased HIF activation post-ischemia has been shown to accelerate the progression to heart failure in genetic mouse models (1), thus failure to fully activate HIF-1α in diabetic hearts would translate to poorer long-term prognosis post-MI. Here, HIF1A is linked to myocardial infarction.