The goal of this study was to determine whether Ghrelin was effective in the inhibition of myocardial fibrosis in the Ang II-infused rats and whether the inhibitory effect of Ghrelin occurred via modulation of the TGF-β1 signaling pathways in a PPAR-γ-dependent manner. The gene discussed is TGFB1; the disease is Myocardial fibrosis.