In adenoma compared to normal top hub genes are APOE (7), NR3C1 (4), and NMU (4), in carcinoma compared to normal top hub genes are AGT (10), BCL2 (10), AURKA (9), MMP3 (6), CDC6 (6), TPX2 (6), PRKACB (6), UB2C (5), SULT1A1 (4), KLF4 (4), ECT2 (4), and MMP1 (4), and in carcinoma compared to adenoma top hub genes are COL3A1 (6), COL1A2 (6), SPARC (5), DCN (5), and SPP1 (4). This evidence concerns the gene SPARC and adenoma.