In recent years, the study showed that the abnormal activation of phosphatidylinositol-3 kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway (e.g., gene mutation) can inhibit the apoptosis of endometrial cancer cells and promote cancer cell proliferation, invasion, and angiogenesis [10, 11]. Here, AKT1 is linked to endometrial cancer.