LEF1 and cancer: For example, many downstream components of the canonical Wnt signaling pathway are misregulated in a variety of cancers (hepatocellular, colorectal, orapharyngeal squamous cell carcinoma) and their associated metastasis including Axins, β-catenin, and TCF/Lef1 transcription factors (Figure 6) (Lammi et al., 2004; Salahshor and Woodgett, 2005; Marvin et al., 2011; Papagerakis et al., 2012).