LIN28B and ovarian cancer: First, both the LIN28B protein and mRNA are strongly expressed in ovarian cancer.26,41,45 Second, a high expression level of LIN28B is significantly associated with the risk of disease progression and death in ovarian cancer patients.41 Third, a polymorphism, rs12194974 (G > A) in the LIN28B promoter region, influences susceptibility to ovarian cancer.42 However, the underlying molecular mechanisms of LIN28B function in ovarian tumorigenesis are still largely unknown.