LIN28B had been identified to act as an oncogene by promoting malignant transformation,26,27,30–33,50 inducing metastasis,27,34–36 regulating inflammation,16,27,37 and maintaining cancer stem cells.27,38–40 Continuous efforts had been exerted to dissect the regulatory networks governed by LIN28B in human cancers. The gene discussed is LIN28B; the disease is cancer.