LIN28A and cancer: This is consistent with a recent study of LIN28A RNA-IP deep sequencing in human ES cells,46 as well as previous reports demonstrating that LIN28A/B controlled G2/M transition in ES cells23 and promoted cancer cell proliferation.47 Interestingly, the DNA damage pathway associated with cancer cell apoptosis was also enriched in our RNA-IP experiments (Fig. 4c and Table S2), which might be a unique function of LIN28B.