TP53 and neoplasm: By performing experiments with del90 p53 variants without the p53 transactivation domain we also excluded that the wt p53 tumor-suppressive transactivation, which leads to severe physiologic consequences in cells - apoptosis, cell cycle arrest and metabolic reprogramming [44] and thus possibly influences the p53-CFP/YFP turnover, localization or folding - is decisive for the more efficient wt p53 oligomerization.