TP53 and cancer: In H1299 cells stability of wt and hot-spot mutant p53 variants is more similar compared to endogenous wt and p53 mutants in cancer cells ([35] and Supplementary Figure 2E) which helps to maintain similar levels of overexpressed wt and mutant p53 variants – an important feature of a model used to compare quantitative effects of p53 variants [14, 36].