We therefore typed a group of myeloma patients for EOMES and Tbet expression, (Supplementary Figure 4A, patient data in Supplementary Table 2), and found that the patients with tumor load of > 10% bone marrow PC had more ‘exhausted’ EOMEShighTbetlow cells amongst their PD1+ CD8+ T cells than the patients with tumor load ≤10% PC (Figure 3A). This evidence concerns the gene CD8A and plasma cell myeloma.