Although we found no evidence of degranulation of PD1+ T cells when co-cultured with autologous myeloma cells, the PD1+ CD8+ T cells proliferated when co-cultured with adherent cells from autologous bone marrow (Figure 3H), but not when cultured on their own (Figure 3I), suggesting that the PD1+ CD8+ T cells may respond to autologous APC (antigen presenting cells). The gene discussed is CD8A; the disease is plasma cell myeloma.