Galleges Ruiz et al. suggested that (1) the EGFR-Stat3 pathway may be related to the tumor growth of early NSCLC (2) pStat3-positive expression in NSCLC may indicate the indolent type, and (3) high pStat3 expression was significantly associated with longer OS and PFS [20]. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.