The inhibitory effects of Ponatinib on individual downstream signal transduction pathways have been reported in various cellular systems, including ERK in multiple CML cell lines [65] and endometrial cancer cells [33], Akt in murine myeloid cells [30] and endometrial cancer cells [33], and p38 MAPK in murine macrophages [66]. The gene discussed is AKT1; the disease is endometrial cancer.