SOD1 and Sepsis: SOD and CAT were increased in septic patients, demonstrating an adaptive antioxidant response to oxidative stress during sepsis, while erythrocyte selenium, erythrocyte glutathione, and selenoprotein P, the main plasma selenoprotein, were markedly decreased in patients with proven or clinical sepsis in comparison to controls, suggesting consumption of selenium-containing antioxidant molecules [64].