CRP and Sepsis: Concordantly, in a recent nonrandomized trial including 40 septic newborns treated with antibiotics and melatonin (20 mg/kg, single dose) or antibiotics alone, melatonin treatment was associated with a significantly stronger reduction of CRP levels and improvement of clinical parameters in comparison to antibiotic treatment alone [99] and it was also shown to improve clinical sepsis score in comparison to antibiotic treatment alone in a cohort of 50 septic newborns [100].