Moreover, prolidase, matrix metalloproteinases, and oxidative-antioxidant status parameters significantly differed in women with chorioamnionitis in comparison to those without chorioamnionitis in the PPROM group and levels of prolidase, matrix metalloproteinase-13, TOS, TAC, and PON-1 were proved to predict chorioamnionitis in the PPROM group [72]. The gene discussed is PON1; the disease is preterm premature rupture of the membranes.