TNF and Neonatal sepsis: Promising results in antioxidant treatment for neonatal sepsis were obtained with the administration of pentoxifylline, which exerts several antioxidant and anti-inflammatory activities, as reduced glutathione level restoration, mitochondrial viability maintenance, inhibition of TNF-alpha production, preservation of proper endothelial function and of proper coagulation activity, and prevention of gastrointestinal vasoconstriction [104].