LTF and Sepsis: Interestingly, in 15 preterm newborns, serum lactoferrin levels were significantly lower in patients with proven sepsis in comparison to those with clinical sepsis and were positively correlated with white blood cell count or absolute neutrophil count, suggesting that the lowest lactoferrin observed in more immature infants is likely related to suboptimal white cell activity and that lactoferrin supplementation could be particularly effective in this population [110].