The endothelin system is well known to be involved in sepsis, as endothelin-1 (ET-1) induces activation of NF-κB-mediated proinflammatory pathways and expression of adhesion molecules [120] and ET-1 levels appear increased in septic newborns, particularly in case of pulmonary hypertension [121, 122]. Here, EDN1 is linked to pulmonary arterial hypertension.