CXCL8 and Sepsis: Levels of IL-6 and IL-8 are significantly increased in septic newborns in comparison to healthy controls, in both early-onset (EOS) and late-onset sepsis (LOS) [10, 11] at least for the first 12–24 hours from the onset of sepsis [10], and were proposed as useful markers for the early diagnosis of sepsis in newborns in experimental settings, and, when available, also in clinical practice [11, 12].