Similar defects were found in muscle biopsies of UCMD and BM patients (Angelin et al., 2007; Merlini et al., 2008a; Grumati et al., 2010), and following the demonstration that reactivation of autophagy by different means is beneficial in recovering the structural and functional defects of Col6a1-/- mice, a pilot clinical trial in UCMD and BM patients by 1-year low-protein diet was successful in reactivating autophagy (Castagnaro et al., 2016). The gene discussed is COL6A1; the disease is Congenital muscular dystrophy, Ullrich type.