GHRH knockout GHRH
−/−(mouse):↓weight, blood and liver IGF1, pituitary growth hormone; pituitary size; adipose tissue expression of adiponectin and visfatin; hypothalamic expression of CRH, norepinephrine; anxiety and depression related behavior↑adiposity; food intake, blood adiponectin, ghrelin, hypothalamic expression of AgRP, NPY; exploratory activity↔ blood leptin. The gene discussed is LEP; the disease is major depressive disorder.