In fact, several pathogenic mutations in ALS occur in genes involved in RNA processing and activity (ANG, TARDBP, FUS, ATXN2, TAF15, MATR3) (Peters et al., 2015) and selective knockout of Dicer, the critical enzyme in microRNA maturation, leads to motor neuron death (Haramati et al., 2010). Here, TARDBP is linked to amyotrophic lateral sclerosis.