Since it is established that E. amylovora requires the exopolysaccharide amylovoran (ams) among others for pathogenicity (Oh and Beer 2005), it is probable that the B-lectin domain of this candidate gene interacts with ams. STKc_IRAK is the serine/threonine signature characteristic of class 5 genes conferring resistance to bacterial diseases (Kruijt et al. 2005). Here, TWIST2 is linked to bacterial infectious disease.