MIF and Cognitive impairment: MIF (30 mg/kg rat ip), and the much more effective C-108297 (20 mg/kg) and C-113176 (10 mg/kg) at a dose of 20 and 10 mg/kg, respectively, twice a day for 5 days, all reversed the precipitation of Alzheimer pathology and cognitive impairment in an animal model generated by hippocampal amyloid-β25−35 administration, while normalizing plasma corticosterone levels (Pineau et al. 2016).