Similar observations were made in the ccRCC cell lines: The significantly lower cellular association of both 125I-HDL and 125I-LDL by 786-O-VHL and RCC4-O-VHL cells was increased by pretreatment with VEGF for 1 h to the same level as observed in 786-O (Fig. 4C, D) and RCC4 cells (supplemental Fig. S8a, b), respectively, with or without treatment with VEGF. The gene discussed is VEGFA; the disease is nonpapillary renal cell carcinoma.