The neutralizing anti-SR-BI-antibody also decreased the cellular association of 125I-HDL and 125I-LDL by RCC4 and RCC4-O-VHL cells (supplemental Fig. S13a, b), as well as in patient-derived ccRCC and normal kidney epithelial cell cultures (Fig. 7A, B). Here, SLC49A4 is linked to nonpapillary renal cell carcinoma.