In principle, the same observations were made for the kinetics of 125I-HDL and 125I-LDL in a pulse chase experiment in the ccRCC cell lines, 786-O and 786-O-VHL (Fig. 3, supplemental Fig. S6): the 786-O-VHL cells showed considerable degradation of 125I-HDL and 125I-LDL as well as resecretion of 125I-HDL, whereas the parental 786-O failed to degrade both 125I-HDL and 125I-LDL. Here, VHL is linked to nonpapillary renal cell carcinoma.