Both the patient-derived ccRCC cell culture and the VHL-deficient cell lines, 786-O and RCC4, showed significantly higher specific cell association of 125I-HDL and 125I-LDL compared with the normal kidney epithelial cells and the retransfected counterpart cell lines, 786-O-VHL and RCC4-VHL: After 1 h of incubation and compared with cultured normal epithelial kidney cells, association of 125I-HDL and 125I-LDL were 50–100% and 80–150% higher, respectively, in the ccRCC-derived cell culture (first two columns of Fig. 2A, B as well as supplemental Fig. S4a, b). The gene discussed is VHL; the disease is nonpapillary renal cell carcinoma.