In contrast, the expression of both the VLDL receptor (VLDLR) and scavenger receptor BI (SR-BI) was found to be increased in ccRCC compared with the normal kidney tissue (5), and to mediate lipid uptake into ccRCC cells from VLDL and HDL, respectively (5, 6). The gene discussed is SCARB1; the disease is nonpapillary renal cell carcinoma.