When RPL10 was knocked-down in PANC-1 and MIA PaCa-2 cells, the expression of OSGIN1 indeed markedly increased, whereas HMOX1 showed little change in both cells (Fig. 3B), indicating that RPL10 is possible to regulate ROS level in pancreatic cancer cells. This evidence concerns the gene HMOX1 and familial pancreatic carcinoma.