In the male group: two out of six mice with orthotopic implantation of A498 cells with over‐expressed ERβ (A498‐ERβ) had metastatic tumors in the diaphragm, liver and hepatic portal lymph nodes as compared to zero out of six mice with A498‐vec control implants (Fig. 6A, right bottom). This evidence concerns the gene ESR2 and metastatic neoplasm.