ESR2 and renal cell carcinoma: A similar conclusion was also made when we compared ERβ staining in different pathological grades; the results showed that 21% (seven of 33) Fuhrman's grade 1 (G1) RCC tumors vs. 49% (23 of 47) grade G2‐3 RCC tumors have higher and stronger ERβ IHC staining signals (P = 0.0184) (Fig. 1B).