ESR2 and renal cell carcinoma: Importantly, we found that Erβ staining signals were mainly detected in the nuclei and its expression increased as RCC progresses to the later stages (T1 vs. T2‐3) or higher grades (G1 vs. G2‐3) (Fig. 1B). The results from TCGA database analysis showed that a higher ERβ expression level was associated with a worse survival rate.