BRF1 and leukemia: Brf1 and Brf2 are involved in early B‐cell development where they regulate senescence to enable recombination at the immunoglobulin locus60 while in T‐cell development they are involved in the β‐selection checkpoint, and loss of Brf1 and ‐2 results in leukemia.61 The roles of Brf1 and ‐2 in innate immune cells are not well understood.