Some studies show that Mg2+ may improve insulin sensitivity and prevent diabetes [8]; however, two cohort studies (13,076 persons/year) indicated that low Mg2+ intake was not a risk factor for diabetes [9], and six randomized controlled trials demonstrated that Mg2+ was not effective for glycemic control in patients with type 2 diabetes (T2D) [9]. The gene discussed is INS; the disease is diabetes mellitus.