It was found that polyphenolic compounds may mediate apoptosis by caspase activation and PARP1 cleavage; for example, Corylus avellana extract contains high amounts of polyphenols induces apoptosis in human malignant melanoma (SK-Mel-28) and human cervical cancer (HeLa) cell lines by this mechanism (Esposito et al. 2017). The gene discussed is PARP1; the disease is melanoma.