Caspase-dependent apoptosis with inactivation of PARP1 has also been observed after treatment of human lymphoblastoid TK6 cells with digallic acid obtained from Pistacia lentiscus fruits (Bhouri et al. 2012) or human colon cancer HCT-116 cells treated with green coffee bean extract (chlorogenic acid complex) (Gouthamchandra et al. 2017). This evidence concerns the gene PARP1 and malignant colon neoplasm.