In comparison of breast carcinomas with regular values of uPA and PAI-1 to carcinomas with an increase of uPA and/or PAI-1, there was lower rate of proliferation (average 8.5%) in the group with non-increased protein levels than in the group with increased protein level (average 13.9%); p = 0.054, Student’s t-test (Fig. 1). Here, PLAU is linked to carcinoma.